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The increased levels of inflammatory cytokine and chemokine genes observed in the intestinal tissues of PD patients suggest a strong connection between PD and intestinal inflammation (85, 90)

Salehi M, Kheiriabadi GR, et al

Autophagy and its therapeutic potential in diabetic nephropathy

Grobs et al

The release of free copper ions, facilitated by transporters such as ATP7A and ATOX1, induces neointimal thickening following vascular injury, contributing directly to lesion development [193, 194]

All experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals of the Algerian Association for Experimental Science (AASEA) and approved by the Ethics Committee of department of Biological Science of the Jijel University